Bozarth M A, Wise R A
Science. 1984 May 4;224(4648):516-7. doi: 10.1126/science.6324347.
Rats never before exposed to opioids rapidly learned to press a lever for microinjections of morphine into the ventral tegmental area. Challenge by a narcotic antagonist produced no signs of physical dependence. Dependence was not seen after long-term morphine infusions into the ventral tegmentum but was seen after similar infusions into the periventricular gray region. Thus a major rewarding property of morphine is independent of the drug's ability to produce physical dependence. These data challenge models of drug addiction that propose physical dependence as necessary for the rewarding effects of opioids.
此前从未接触过阿片类药物的大鼠很快学会了按压杠杆，以便将吗啡微量注射到腹侧被盖区。用麻醉拮抗剂进行激发未产生身体依赖的迹象。向腹侧被盖区长期输注吗啡后未出现依赖，但向室周灰质区域进行类似输注后出现了依赖。因此，吗啡的一种主要奖赏特性独立于该药物产生身体依赖的能力。这些数据对将身体依赖视为阿片类药物奖赏效应所必需的药物成瘾模型提出了挑战。
