阿片类物质和下丘脑泌素对腹侧被盖区神经元亚群的神经调节。
Opioid and hypocretin neuromodulation of ventral tegmental area neuronal subpopulations.
机构信息
Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Center for Neural Science, New York University, New York, NY, USA.
出版信息
Br J Pharmacol. 2018 Jul;175(14):2825-2833. doi: 10.1111/bph.13993. Epub 2017 Sep 26.
UNLABELLED
The current view of the midbrain dopaminergic system is evolving towards a complex system of subpopulations of neurons with distinct afferent and efferent connections and, importantly, functionally different intrinsic characteristics. Recent literature on the phenotypic diversity of dopaminergic neurons has outlined that in the ventral tegmental area dopaminergic neurons are not as anatomically or electrophysiologically homogeneous as they were once thought to be. Instead, the midbrain dopaminergic system is now understood to be composed of anatomically and functionally heterogeneous dopaminergic subpopulations receiving specific afferent inputs and with different axonal projections. An additional layer of complexity is the neuromodulation of each of these dopaminergic circuits. This review will examine the distinguishing electrophysiological and neuromodulatory characteristics of the afferent and efferent connections of midbrain dopaminergic neurons.
LINKED ARTICLES
This article is part of a themed section on Emerging Areas of Opioid Pharmacology. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.14/issuetoc.
未加标签
中脑多巴胺能系统的当前观点正在向具有不同传入和传出连接的神经元亚群的复杂系统发展，重要的是，具有不同内在功能特性。最近关于多巴胺能神经元表型多样性的文献概述表明，在腹侧被盖区，多巴胺能神经元在解剖学上或电生理学上并不像曾经认为的那样同质。相反，现在认为中脑多巴胺能系统由解剖学和功能上不同的多巴胺能亚群组成，这些亚群接收特定的传入输入，并具有不同的轴突投射。一个额外的复杂层次是对这些多巴胺能回路中的每一个进行神经调制。这篇综述将探讨中脑多巴胺能神经元传入和传出连接的区分电生理和神经调制特征。
相关文章
本文是关于阿片类药物药理学新兴领域的专题部分的一部分。要查看本节中的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.14/issuetoc.
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