致病钙晶体的临床意义。
Clinical implications of pathogenic calcium crystals.
机构信息
aSorbonne Paris Cité, University Paris Diderot bInserm, UMR S606/1332, Centre Viggo Petersen, Hôpital Lariboisière cAP-HP, Hôpital Lariboisière, Pôle Appareil Locomoteur, Service de Rhumatologie A, Centre Viggo Petersen, Paris, France.
出版信息
Curr Opin Rheumatol. 2014 Mar;26(2):192-6. doi: 10.1097/BOR.0000000000000038.
PURPOSE OF REVIEW
The role of intraarticular calcifications has been challenged over the past years, with respect to cartilage destruction, especially in osteoarthritis.
RECENT FINDINGS
Main themes reviewed in this article will discuss prevalence of articular cartilage calcifications, mechanisms of cartilage calcifications, and mostly the pathogenic role of both calcium pyrophosphate and basic calcium phosphate crystals.
SUMMARY
A direct pathogenic role of both calcium crystals has been depicted, in cartilage as a crystal-induced stress, or via acute or chronic crystal-induced synovitis.
目的综述
近年来，关节内钙化在软骨破坏方面的作用受到质疑，尤其是在骨关节炎中。
最新发现
本文主要讨论了关节软骨钙化的患病率、软骨钙化的机制，以及焦磷酸钙和碱性磷酸钙晶体的主要致病作用。
总结
钙晶体直接在软骨中引发晶体诱导的应力，或通过急性或慢性晶体诱导的滑膜炎导致致病作用。
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