甘油醛及其他简单单糖对氧合血红蛋白的氧化作用。
The oxidation of oxyhaemoglobin by glyceraldehyde and other simple monosaccharides.
作者信息
Thornalley P J, Wolff S P, Crabbe M J, Stern A
出版信息
Biochem J. 1984 Feb 1;217(3):615-22. doi: 10.1042/bj2170615.
Abstract
Glyceraldehyde and other simple monosaccharides oxidize oxyhaemoglobin to methaemoglobin in phosphate buffer at pH 7.4 and 37 degrees C, with the concomitant production of H2O2 and an alpha-oxo aldehyde derivative of the monosaccharide. Simple monosaccharides also reduce methaemoglobin to ferrohaemichromes (non-intact haemoglobin) at pH 7.4 and 37 degrees C. Carbonmonoxyhaemoglobin is unreactive towards oxidation by autoxidizing glyceraldehyde. Free-radical production from autoxidizing monosaccharides with haemoglobins was observed by the e.s.r. technique of spin trapping with the spin trap 5,5-dimethyl-l-pyrroline N-oxide. Hydroxyl and l-hydroxyalkyl radical production observed from monosaccharide autoxidation was quenched in the presence of oxyhaemoglobin and methaemoglobin. The haemoglobins appear to quench the free radicals by reaction with the free radicals and/or the ene-diol precursor of the free radical.
摘要
在pH 7.4和37摄氏度的磷酸盐缓冲液中，甘油醛和其他简单单糖可将氧合血红蛋白氧化为高铁血红蛋白，同时产生过氧化氢和单糖的α-氧代醛衍生物。在pH 7.4和37摄氏度时，简单单糖还可将高铁血红蛋白还原为高铁血红素（非完整血红蛋白）。碳氧血红蛋白对自氧化甘油醛的氧化无反应。通过使用自旋捕获剂5,5-二甲基-1-吡咯啉N-氧化物的电子自旋共振技术观察到，自氧化单糖与血红蛋白产生自由基。在氧合血红蛋白和高铁血红蛋白存在的情况下，单糖自氧化产生的羟基和1-羟烷基自由基的生成被淬灭。血红蛋白似乎通过与自由基和/或自由基的烯二醇前体反应来淬灭自由基。
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