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本文引用的文献

1
Intracellular transport and degradation of 125I-Labelled denatured serum albumin in isolated nonparenchymal rat liver cells.125I标记的变性血清白蛋白在离体大鼠非实质肝细胞中的细胞内转运与降解
Biochim Biophys Acta. 1982 Dec 30;721(4):469-77. doi: 10.1016/0167-4889(82)90103-3.
2
Perisinusoidal stellate cells (fat-storing cells, interstitial cells, lipocytes), their related structure in and around the liver sinusoids, and vitamin A-storing cells in extrahepatic organs.肝窦周星状细胞（贮脂细胞、间质细胞、脂肪细胞）、肝血窦内及其周围的相关结构以及肝外器官中的维生素A储存细胞。
Int Rev Cytol. 1980;66:303-53. doi: 10.1016/s0074-7696(08)61977-4.
3
Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages.低密度脂蛋白的丙二醛改变导致人单核细胞-巨噬细胞中胆固醇酯积累。
Proc Natl Acad Sci U S A. 1980 Apr;77(4):2214-8. doi: 10.1073/pnas.77.4.2214.
4
Specificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins.受体介导的丙二醛修饰低密度脂蛋白识别的特异性
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1712-6. doi: 10.1073/pnas.79.6.1712.
5
Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.经培养的内皮细胞预先孵育的低密度脂蛋白，其巨噬细胞降解作用增强：通过乙酰化低密度脂蛋白受体识别。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6499-503. doi: 10.1073/pnas.78.10.6499.
6
The scavenger cell pathway for lipoprotein degradation: specificity of the binding site that mediates the uptake of negatively-charged LDL by macrophages.脂蛋白降解的清道夫细胞途径：介导巨噬细胞摄取带负电荷低密度脂蛋白的结合位点的特异性。
J Supramol Struct. 1980;13(1):67-81. doi: 10.1002/jss.400130107.
7
Improved method for purification of enterotoxin from Clostridium perfringens type A.从A型产气荚膜梭菌中纯化肠毒素的改进方法。
Appl Environ Microbiol. 1980 Jun;39(6):1120-2. doi: 10.1128/aem.39.6.1120-1122.1980.
8
Processing of acetylated human low-density lipoprotein by parenchymal and non-parenchymal liver cells. Involvement of calmodulin?实质和非实质肝细胞对乙酰化人低密度脂蛋白的处理。钙调蛋白的参与？
Biochem J. 1982 Nov 15;208(2):493-503. doi: 10.1042/bj2080493.
9
The use of formaldehyde-treated 131-I-albumin in the study of digestive vacuoles and some properties of these particles from mouse liver.甲醛处理的131-I-白蛋白在小鼠肝脏消化液泡及这些颗粒的某些特性研究中的应用。
J Cell Biol. 1967 Mar;32(3):699-707. doi: 10.1083/jcb.32.3.699.
10
An improved method for the preparation of iodinated antigens for radioimmunoassay.一种改进的用于放射免疫分析的碘化抗原制备方法。
J Endocrinol. 1974 Mar;60(3):527-8. doi: 10.1677/joe.0.0600527.

经清道夫途径的甲醛处理血清白蛋白在肝内皮细胞中的内吞作用。

Endocytosis of formaldehyde-treated serum albumin via scavenger pathway in liver endothelial cells.

作者信息

Blomhoff R, Eskild W, Berg T

出版信息

Biochem J. 1984 Feb 15;218(1):81-6. doi: 10.1042/bj2180081.

DOI:10.1042/bj2180081
PMID:6324753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1153310/
Abstract

Denatured or modified proteins (including albumin and low-density lipoprotein) are catabolized in vitro via scavenger receptors. We have studied the distribution of formaldehyde-denatured albumin in rat liver cells after intravenous injection of tracer doses of the protein. At 12 min after injection, most of the formaldehyde-denatured albumin (about 70% of the injected dose) was recovered in liver endothelial cells. Furthermore, isolated liver endothelial cells in suspension and in surface culture took up formaldehyde-denatured albumin by receptor-mediated endocytosis. Our data indicate that the scavenger receptor in liver is mainly located on the endothelial cells. Implications for the catabolism of low-density lipoproteins are discussed.

摘要

变性或修饰的蛋白质（包括白蛋白和低密度脂蛋白）在体外通过清道夫受体进行分解代谢。我们研究了静脉注射示踪剂量的蛋白质后，甲醛变性白蛋白在大鼠肝细胞中的分布情况。注射后12分钟，大部分甲醛变性白蛋白（约占注射剂量的70%）在肝内皮细胞中被发现。此外，悬浮培养和贴壁培养的分离肝内皮细胞通过受体介导的内吞作用摄取甲醛变性白蛋白。我们的数据表明，肝脏中的清道夫受体主要位于内皮细胞上。文中还讨论了其对低密度脂蛋白分解代谢的意义。