Castelli A, Fimiani M, Mancianti M L, Raffaelli M, Flori M L, Valentino A
Boll Soc Ital Biol Sper. 1984 Mar 30;60(3):479-83.
In order to look for a new culture system suitable for investigating on melanocyte biology, in-vitro experiments have been carried out on pigmented basal cell carcinoma, pigmented seborrhoeic keratosis and melanocytic nevus. Melanocytes cultured from pigmented basal cell carcinoma and pigmented seborrheic keratosis are dendritic and DOPA positive. These cells can be considered similar to those of normal skin. Pigmented cells cultured from nevi are quite different. They are spindle-shaped and only to a little extent are DOPA positive. These findings suggest that nevus cells could be non mature melanocytes stopped at an intermediate stage of differentiation.
为了寻找一种适合研究黑素细胞生物学的新培养系统，已对色素性基底细胞癌、色素性脂溢性角化病和黑素细胞痣进行了体外实验。从色素性基底细胞癌和色素性脂溢性角化病培养的黑素细胞呈树突状且多巴阳性。这些细胞可被认为与正常皮肤的细胞相似。从痣培养的色素细胞则大不相同。它们呈纺锤形，仅在很小程度上多巴阳性。这些发现表明痣细胞可能是停留在分化中间阶段的未成熟黑素细胞。
