Voigt M M, Wang R Y
Brain Res. 1984 Mar 26;296(1):189-93. doi: 10.1016/0006-8993(84)90531-6.
We observed that the release of endogenous dopamine (DA), induced by perfusion of a 55 mM K+-containing buffer in the nucleus accumbens, was Ca2+-dependent and confined to a local region. We also demonstrated that the sulphated form of cholecystokinin octapeptide, but not the unsulphated form, suppressed this stimulated release of dopamine in a concentration-dependent manner. This suggests that cholecystokinin may act as a functional antagonist to dopamine within this structure.
我们观察到，通过向伏隔核灌注含55 mM钾离子的缓冲液诱导内源性多巴胺（DA）释放，这种释放依赖于钙离子且局限于局部区域。我们还证明，八肽胆囊收缩素的硫酸化形式而非非硫酸化形式，以浓度依赖的方式抑制这种刺激引起的多巴胺释放。这表明胆囊收缩素可能在该结构中作为多巴胺的功能性拮抗剂发挥作用。
