Polonis V R, Anderson G R, Brzykcy J, Vladutiu A O, Manly K F
Cancer Res. 1984 May;44(5):2236-9.
An unusual isozyme of lactate dehydrogenase, lactate dehydrogenase associated with Kirsten murine sarcoma virus (LDHk) was found in the sera of many patients with malignant tumors, while the sera of healthy persons had little or no such activity. This isozyme was detectable only when assayed in a nitrogen atmosphere, and its activity showed little or no relationship to the total lactate dehydrogenase activity as measured by a standard clinical assay. The activity of serum LDHk appeared to be correlated with the presence of known metastases. Increased serum LDHk appeared in a wide variety of patients with cancer, although it appeared to be more common in certain types of cancer. Increased serum LDHk activity was also found in the sera of some patients with nonmalignant disease. The activity of serum LDHk may be useful to monitor recurrence or response to therapy in certain types of cancer.
一种不寻常的乳酸脱氢酶同工酶，即与 Kirsten 小鼠肉瘤病毒相关的乳酸脱氢酶（LDHk），在许多恶性肿瘤患者的血清中被发现，而健康人的血清中这种活性很低或没有。这种同工酶只有在氮气氛围中检测时才能被检测到，并且其活性与通过标准临床检测方法测得的总乳酸脱氢酶活性几乎没有关系。血清 LDHk 的活性似乎与已知转移灶的存在相关。血清 LDHk 升高出现在各种各样的癌症患者中，尽管在某些类型的癌症中似乎更常见。在一些非恶性疾病患者的血清中也发现了血清 LDHk 活性升高。血清 LDHk 的活性可能有助于监测某些类型癌症的复发或对治疗的反应。
