Gar'kavyĭ M I, Kovner F Ia, Narbutene G L
Vopr Onkol. 1978;24(1):34-8.
The isoenzymic spectrum of lactate dehydrogenase of blood sera was studied in 170 patients with malignant and benign tumors, chronic inflammatory lesions and in healthy persons. The characteristic changes in patients with malignant tumors were as follows: an increased activity of slow fractions and a decreased one in rapidly migrating fractions. The level of the 5th isoenzyme activity and the frequency of its increased activity in serum correlated well with the degree of cancer spread. The determination of a percentual content of the isoenzyme may be used as a supplementary test for diagnosing metastic involvement of the liver. The examination of the serum lactate dehydrogenase spectrum in patients with benign tumors and chronic inflammatory disease revealed no changes characteristic of malignant neoplasms.
对170例患有恶性和良性肿瘤、慢性炎症病变的患者以及健康人的血清乳酸脱氢酶同工酶谱进行了研究。恶性肿瘤患者的特征性变化如下：慢迁移组分活性增加，快迁移组分活性降低。血清中第5种同工酶活性水平及其活性增加的频率与癌症扩散程度密切相关。同工酶百分比含量的测定可作为诊断肝脏转移受累的补充检查。对良性肿瘤和慢性炎症疾病患者的血清乳酸脱氢酶谱检查未发现恶性肿瘤特有的变化。
