Furuta S, Obata E, Hanamure Y, Fukuda K, Fukami K, Ohyama M
Jpn J Antibiot. 1983 Oct;36(10):2742-9.
Basic and clinical studies on cefotiam (CTM) for the infectious diseases in otorhinolaryngological field were performed and the following results were obtained. The peak value in the serum level of CTM was 18.05 micrograms/ml by 0.5 g administration and 35.2 micrograms/ml by 1 g at 30 minutes after a single intravenous injection. CTM was rapidly excreted from the blood after injection and was detected a little amount in serum at 6 hours after the administration. Tissue concentrations of the drug into palatine tonsil and the mucous membrane of the nasal cavity or maxillary sinus were seen in relatively rapid and good manner. Chemotherapeutic results excepting Pseudomonas aeruginosa infections (3 cases) were excellent in 2 cases, good in 7 cases and poor in 3 cases of 12 patients with the infectious diseases in otorhinolaryngological field. No adverse effects and abnormal values in the laboratory findings were revealed in every patients.
针对耳鼻咽喉科领域的感染性疾病，开展了头孢替安（CTM）的基础及临床研究，并获得了以下结果。单次静脉注射后30分钟，给予0.5g剂量时CTM血清水平峰值为18.05微克/毫升，给予1g剂量时为35.2微克/毫升。注射后CTM从血液中迅速排出，给药6小时后血清中仅检测到少量。药物在腭扁桃体以及鼻腔或上颌窦黏膜中的组织浓度呈现出相对快速且良好的状态。在12例耳鼻咽喉科感染性疾病患者中，除铜绿假单胞菌感染（3例）外，2例化疗效果极佳，7例良好，3例较差。所有患者均未出现不良反应及实验室检查异常值。
