Tanaka N, Okamoto E, Toyosaka A, Nakao N
Nihon Geka Gakkai Zasshi. 1983 Jun;84(6):518-28.
Ischemic effect of interruption of hepatic artery upon the expansively growing primary carcinoma of the liver was studied on six resected specimens obtained by hepatectomy having been carried out 10 to 35 days after HAL or TAE. Both HAL and TAE were found to bring about an extensive coagulative necrosis in the main tumor. No substantial difference was observed between the two in the degree or the mode of necrosis produced. Complete necrosis of the tumor was observed in a case of a nodular type hepatoma in the visceral aspect of the right posterior segment. An incomplete necrosis was obtained in the main tumor of remaining 5 cases. The necrotized region was clearly demarcated from the viable portion in the tumor by the septal formation which was probably used to be the part of the capsule around the tumor. This suggested that the compartment in the tumor separated by these septa is supplied by the different artery independently. Therefore, if the interruption therapy is chosen as the sole procedure, it is stressed that complete hepatic dearterialization is mandatory for the treatment of liver cancer.
对6例在肝动脉结扎（HAL）或经动脉栓塞化疗（TAE）后10至35天进行肝切除所获得的切除标本，研究了肝动脉阻断对肝脏膨胀性生长的原发性癌的缺血效应。发现HAL和TAE均在主要肿瘤中引起广泛的凝固性坏死。在产生坏死的程度或方式上，两者之间未观察到实质性差异。在右后段脏面的一例结节型肝癌病例中观察到肿瘤完全坏死。其余5例主要肿瘤出现不完全坏死。坏死区域通过间隔形成与肿瘤中的存活部分清晰分界，该间隔可能曾是肿瘤周围包膜的一部分。这表明由这些间隔分隔的肿瘤中的隔室由不同的动脉独立供血。因此，如果选择阻断治疗作为唯一的治疗方法，强调完全肝去动脉化对于肝癌治疗是必不可少的。
