Lin M T, Chen C F, Chuang K S
Neuropharmacology. 1984 Feb;23(2A):129-35. doi: 10.1016/s0028-3908(84)80004-0.
Following administration of dibutyryl cyclic-AMP or aminophylline, but not vehicle solution, into the lateral cerebral ventricle of rats produced locomotor stimulation, head and body rearing, circling, (as indicated by an enhancement of gross movement), increased grooming, head swaying and scratching (as indicated by an enhancement of fine movement), tail elevation, piloerection and convulsion. The behavioural excitation produced by either dibutyryl cyclic-AMP or aminophylline was antagonized by pretreatment with intraventricular injection of either two alpha-adrenergic antagonists (phentolamine and yohimbine) or a dopaminergic antagonist (haloperidol), but not with either a beta-adrenergic antagonist (propranolol) or a narcotic antagonist (naloxone). In addition, direct administration of dibutyryl cyclic-AMP into either the anterior hypothalamus, the nucleus accumbens or the caudate-putamen complex of rats produced the same behavioural responses as those produced by the intraventricular injection. Again, the behavioural responses induced by intracerebral injection of dibutyryl cyclic-AMP was antagonized by pretreatment with either alpha-adrenergic antagonists or a dopaminergic antagonist. The present data indicate that both the dopaminergic and the adrenergic receptors in the brain are involved in the behavioural excitation induced by dibutyryl cyclic-AMP and aminophylline in the rat.
向大鼠侧脑室注射二丁酰环磷腺苷或氨茶碱（而非溶剂）后，会产生运动刺激、头部和身体抬起、转圈（表现为总体运动增强）、梳理毛发增加、头部摆动和抓挠（表现为精细运动增强）、尾巴抬起、竖毛和惊厥。脑室注射两种α-肾上腺素能拮抗剂（酚妥拉明和育亨宾）或多巴胺能拮抗剂（氟哌啶醇）预处理可拮抗二丁酰环磷腺苷或氨茶碱产生的行为兴奋，但β-肾上腺素能拮抗剂（普萘洛尔）或阿片拮抗剂（纳洛酮）则不能。此外，直接向大鼠下丘脑前部、伏隔核或尾状核-壳核复合体注射二丁酰环磷腺苷会产生与脑室注射相同的行为反应。同样，脑内注射二丁酰环磷腺苷诱导的行为反应可被α-肾上腺素能拮抗剂或多巴胺能拮抗剂预处理所拮抗。目前的数据表明，大脑中的多巴胺能和肾上腺素能受体均参与了二丁酰环磷腺苷和氨茶碱在大鼠中诱导的行为兴奋。
