Eschmann G, Irrgang V, Rüther E
Neuropsychobiology. 1983;10(2-3):190-2. doi: 10.1159/000118008.
10 normal volunteers (5 females, 5 males, 18-30 years) were treated for 4 days with the beta-blocker sotalol, 320 or 960 mg/day, 5 persons each in random order. A placebo was applied 5 days before and 2 days afterwards. Changes in blood pressure and pulse were not pronounced. EEG data from vigilance-controlled EEGs, evaluated in a spectral parameter analysis, showed a significant decrease of the absolute and relative alpha-power and the dominant alpha-amplitude and so far indicate a central nervous system action of sotalol.
10名正常志愿者（5名女性，5名男性，年龄18 - 30岁）接受了为期4天的β受体阻滞剂索他洛尔治疗，剂量为320或960毫克/天，每组5人，随机安排用药顺序。在用药前5天和用药后2天使用安慰剂。血压和脉搏变化不明显。通过频谱参数分析评估的警觉性控制脑电图的脑电图数据显示，绝对和相对α波功率以及主导α波振幅显著降低，目前表明索他洛尔有中枢神经系统作用。
