Cohen G
Neurotoxicology. 1984 Spring;5(1):77-82.
This article summarizes the evidence that oxy-radicals are involved in the destruction of catecholamine neurons by polyphenolic neurotoxins. Superoxide-mediated damage by 6-hydroxydopamine can be suppressed by intracellular catecholamines, which act as scavengers of the superoxide radical. Administration of exogenous hydroxyl radical-scavenging agents protects peripheral sympathetic neurons from destruction by 6-hydroxydopamine, 6- aminodopamine or 5,7-dihydroxytryptamine. Intraneuronal monoamine oxidase may drive cellular senescence of the nigrostriatal tract in patients with Parkinson's disease by generating hydrogen peroxide and derived oxy-radicals during the metabolism of endogenous dopamine.
本文总结了氧化自由基参与多酚类神经毒素对儿茶酚胺能神经元破坏的证据。细胞内儿茶酚胺作为超氧阴离子自由基的清除剂，可以抑制6-羟基多巴胺介导的超氧化物损伤。给予外源性羟基自由基清除剂可保护外周交感神经元免受6-羟基多巴胺、6-氨基多巴胺或5,7-二羟基色胺的破坏。帕金森病患者黑质纹状体通路中的神经元内单胺氧化酶在代谢内源性多巴胺的过程中，可能通过生成过氧化氢和衍生的氧化自由基来驱动细胞衰老。
