Lin J S, Radnay K, Kendrick M I, Rosner B, Kass E H
J Infect Dis. 1978 Mar;137(3):266-73. doi: 10.1093/infdis/137.3.266.
Titers of mycoplasmacidal antibody to the human genital mycoplasmas Ureaplasma urealyticum and Mycoplasma hominis were determined using genital isolates from pregnant patients as antigens and comparing these isolates with the 11 prototypic reference strains for U. urealyticum and the seven reference strains for M. hominis. Virtually all titers that were detected with use of the patient's own isolates were detected by the 11 reference strains of U. urealyticum and by the seven reference strains of M. hominis. Serologic surveys of pregnant women who harbored either or both mycoplasmas in vaginal cultures indicated that antibody to M. hominis was found more commonly than antibody to U. urealyticum. It was demonstrated that significant postpartum rises in titers of antibody to M. hominis were correlated with the presence of these mycoplasmas in genital cultures. Postpartum rises in titer of antibody were particularly likely to occur in women with low titers of mycoplasmacidal antibody in serum at the time of delivery. Approximately 88% of the women who were colonized with M. hominis showed significant changes in titer of antibody to M. hominis throughout an apparently normal pregnancy; only 40% of the women who were colonized with U. urealyticum showed such changes in titers to U. urealyticum. Statistical analysis showed that mean log titers of antibody to both mycoplasmas at the first prenatal visit were significantly associated with the number of pregnancies experienced by these women.
以孕妇生殖道分离株为抗原，将这些分离株与解脲脲原体的11株原型参考菌株及人型支原体的7株参考菌株进行比较，测定了针对人泌尿生殖道支原体解脲脲原体和人型支原体的杀支原体抗体效价。实际上，使用患者自身分离株检测到的所有效价，用解脲脲原体的11株参考菌株和人型支原体的7株参考菌株也都能检测到。对阴道培养物中携带一种或两种支原体的孕妇进行的血清学调查表明，人型支原体抗体比解脲脲原体抗体更常见。结果表明，产后人型支原体抗体效价显著升高与生殖道培养物中存在这些支原体有关。抗体效价的产后升高尤其可能发生在分娩时血清中杀支原体抗体效价较低的女性身上。在整个看似正常的孕期中，约88%感染人型支原体的女性人型支原体抗体效价有显著变化；而感染解脲脲原体的女性中，只有40%的解脲脲原体抗体效价有此类变化。统计分析表明，首次产前检查时两种支原体抗体的平均对数效价与这些女性的妊娠次数显著相关。
