Garcea N, Campo S, Siccardi P, Panetta V, Venneri M, Dargenio R
Acta Eur Fertil. 1983 Jan-Feb;14(1):35-40.
This study was performed on 8 patients with normal levels of PRL and ovulatory cycles. Three of these patients were treated with 5 mg/day Bromocriptine and three of them with 60 mg/day Metoclopramide from the beginning of the cycle in order to induce hypo- and hyperprolactinemia respectively. The other two women were left as control. Daily blood samples were collected for the determination of PRL, LH 17 beta-Estradiol and Progesterone. Patients were operated on between the 6th and the 8th day after the LH peak and corpora lutea enucleated and frozen for subsequent 125I-LH binding tests. An analysis of our data demonstrates that hypo- and hyper- prolactinemia induced with Bromocriptine and Metoclopramide respectively may cause luteal insufficiency, which is revealed by decreased blood levels of progesterone. Furthermore we have observed that specific binding for LH in human luteal tissue is always present (in normal, hypo- and hyperprolactinemic women) but is reduced in presence of very high or very low levels of PRL.
本研究对8名催乳素水平正常且有排卵周期的患者进行。其中3名患者从周期开始时起每天服用5毫克溴隐亭，另外3名患者每天服用60毫克甲氧氯普胺，以分别诱导低催乳素血症和高催乳素血症。另外两名女性作为对照。每天采集血样以测定催乳素、促黄体生成素、17β - 雌二醇和孕酮。患者在促黄体生成素峰值后的第6天至第8天进行手术，摘除黄体并冷冻，用于后续的125I - 促黄体生成素结合试验。对我们数据的分析表明，分别用溴隐亭和甲氧氯普胺诱导的低催乳素血症和高催乳素血症可能会导致黄体功能不全，这通过孕酮血水平降低得以体现。此外，我们观察到，人黄体组织中促黄体生成素的特异性结合总是存在（在正常、低催乳素血症和高催乳素血症女性中），但在催乳素水平非常高或非常低时会降低。
