Nyerges G, Mészner Z, Simon M
Acta Microbiol Hung. 1983;30(3-4):211-5.
Varicella-zoster virus (VZV)-specific antibodies were tested by indirect membrane immunofluorescent technique in sera of 32 immunocompromized children during the first week after onset of varicella. VZV-specific IgM antibodies were found in sera of all but four patients. Three of the four IgM negative patients were followed up, and it was demonstrated that all of them gave a retarded antibody response. They had severe leukopenia and had several relapses of their VZV-infection. The results indicate (a) that the demonstration of VZV-specific IgM antibodies is of diagnostic value even in atypical varicella of immunocompromized patients; and (b) that in cases with retarded antibody response relapses can be expected.
采用间接膜免疫荧光技术，对32名水痘发病第一周内的免疫功能低下儿童血清中的水痘带状疱疹病毒（VZV）特异性抗体进行了检测。除4名患者外，其余所有患者血清中均检测到VZV特异性IgM抗体。对4名IgM阴性患者中的3名进行了随访，结果表明他们均出现抗体反应延迟。他们患有严重白细胞减少症，并且VZV感染多次复发。结果表明：（a）即使在免疫功能低下患者的非典型水痘中，VZV特异性IgM抗体的检测也具有诊断价值；（b）在抗体反应延迟的病例中，可能会出现复发情况。
