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内质网增殖增加时粗面内质网与核膜之间的相互作用。

Interactions between the rough endoplasmic reticulum and the nuclear membrane during increased proliferation of the endoplasmic reticulum.

作者信息

Banjo A O

出版信息

Afr J Med Med Sci. 1983 Sep-Dec;12(3-4):145-54.

PMID:6326548
Abstract

Flickinger (1978) has shown conclusively that when there is demand for membrane by the nucleus, such as during repair of a damaged nuclear envelope, several membrane continuities develop between the RER and the nuclear envelope. This experiment was set up to determine if reversal of flow of membrane from the nuclear envelope to the RER would occur during phenobarbital-stimulated increased synthesis of RER. During the increased synthesis of RER following the stimulation of liver cells, it was observed that there was increase in the number of membrane continuities between the RER and the nuclear envelope. Increased blebbing and vesicle formation from the nuclear envelope was also seen. These vesicles were liberated as RER into the cytoplasm. It is therefore suggested that the nuclear envelope and the RER are in a state of equilibrium (RER in equilibrium NE) and membrane can be transferred either way depending on demand through the many membrane continuities that develop between the two organelles.

摘要

弗利金杰(1978年)已确凿表明,当细胞核对膜有需求时,比如在受损核膜修复期间,糙面内质网(RER)和核膜之间会形成几条膜连续性结构。本实验旨在确定在苯巴比妥刺激导致糙面内质网合成增加的过程中,是否会发生膜从核膜向糙面内质网的反向流动。在肝细胞受到刺激后糙面内质网合成增加的过程中,观察到糙面内质网与核膜之间的膜连续性结构数量增加。还可见核膜的泡状形成和小泡形成增加。这些小泡作为糙面内质网释放到细胞质中。因此,有人提出核膜和糙面内质网处于平衡状态(糙面内质网与核膜平衡),并且膜可以根据需求通过在这两个细胞器之间形成的许多膜连续性结构双向转移。

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