Banjo A O
Afr J Med Med Sci. 1982 Sep;11(3):135-50.
Ingestion or administration of lipid soluble drugs, e.g. phenobarbital to human or animal, induces the liver cells to produce drug-metabolizing enzymes. The process of enzyme synthesis which takes place in the endoplasmic reticulum, is a sequential event and can be divided into three stages as seen on the electron micrographs. The first stage is the period of increased production of the rough endoplasmic reticulum (RER) and the hypertrophy of the same in the cytoplasm. During the period of RER production, the various drug metabolizing enzymes are also being synthesized in the RER. After the completion of enzyme synthesis. The probable 'saturation' of the RER membranes with the enzymes, the RER begins to shed its attached ribosomes at specific points on the membrane, hitherto designated as conversion points, to become the smooth endoplasmic reticulum (SER) with the same attached enzymes. The new SER accumulates at distinct areas in the cytoplasm also designated as RER leads to SER conversion centres. Each conversion centre consists of a central core of net-like SER tubules surrounded by finger-like tubules of RER which converge radially on the SER core. There are membrane continuities between the SER in the core and the peripherally converging RER. The conversion centres are randomly distributed in the cytoplasm. They are neither related to any organelle nor polarised in respect to the poles of the cell.
摄入或给人类或动物施用脂溶性药物，例如苯巴比妥，会诱导肝细胞产生药物代谢酶。在内质网中发生的酶合成过程是一个连续的事件，从电子显微镜照片上可以分为三个阶段。第一阶段是粗面内质网（RER）产量增加并在细胞质中肥大的时期。在RER产生期间，各种药物代谢酶也在RER中合成。酶合成完成后。RER膜可能被酶“饱和”，RER开始在膜上的特定点脱落其附着的核糖体，这些点迄今被称为转化点，从而变成带有相同附着酶的滑面内质网（SER）。新的SER在细胞质中不同区域积累，这些区域也被称为RER向SER的转化中心。每个转化中心由一个网状SER小管的中央核心组成，周围是RER的指状小管，它们呈放射状汇聚在SER核心上。核心中的SER与周边汇聚的RER之间存在膜连续性。转化中心随机分布在细胞质中。它们既不与任何细胞器相关，也不相对于细胞的两极极化。
