Nakamura H, Oi H, Tanaka T, Hori S, Tokunaga K, Yoshioka H, Kuroda C, Okamura J, Sakurai M, Taguchi T
Gan To Kagaku Ryoho. 1984 Apr;11(4):789-97.
Transcatheter chemo-embolization is a technique for achieving a marked antitumor effect by embolizing the hepatic artery with a gelatin sponge immediately after infusion of adriamycin 60 mg into the same artery. Chemo-embolization was performed in 212 cases of hepatocellular carcinoma and 23 cases of metastatic liver cancer, a total of 235 patients. Of this population, 19 patients with hepatocellular carcinoma underwent hepatectomy, and in 7 of them, complete necrosis of tumors having thick capsules and less than 4 cm in diameter was confirmed. The cumulative survival rate of patients with unresected hepatocellular carcinoma was 75.6% at 6 months, 52.6% at 1 year, and 20.3% at 2 years. The longest survival time was 3 years and a half, and this patient is now living. As regards metastatic liver cancer, complete necrosis could be achieved in 1 of 2 patients undergoing resection, whereas the cumulative survival rate of unresected cases was 55% at 6 months and 44% at 1 year: only two patients survived for more than 1 year. Technically, the use of a balloon catheter (7F) resulted in the virtual elimination of unsuccessful cases and the prevention of adverse effects due to migration of the gelatin sponge.
经导管化疗栓塞是一种技术，即在向肝动脉注入60毫克阿霉素后立即用明胶海绵栓塞该动脉，以实现显著的抗肿瘤效果。对212例肝细胞癌和23例转移性肝癌患者，共235例进行了化疗栓塞。在这组患者中，19例肝细胞癌患者接受了肝切除术，其中7例证实直径小于4厘米且有厚包膜的肿瘤完全坏死。未切除的肝细胞癌患者6个月时的累积生存率为75.6%，1年时为52.6%，2年时为20.3%。最长生存时间为3年半，该患者目前仍在世。对于转移性肝癌，2例接受切除术的患者中有1例可实现完全坏死，而未切除病例的累积生存率6个月时为55%，1年时为44%：只有2例患者存活超过1年。从技术上讲，使用球囊导管（7F）几乎消除了失败病例，并防止了因明胶海绵迁移导致的不良反应。
