Zalcberg J R, Thompson C H, Lichtenstein M, Leyden M J, Andrews J T, Sullivan J R, McKenzie I F
Aust N Z J Med. 1983 Dec;13(6):571-7. doi: 10.1111/j.1445-5994.1983.tb02605.x.
A radiolabelled monoclonal antibody was injected intravenously into two patients with disseminated carcinoma of the colon and serial scintigrams were then obtained on three consecutive days. In addition to the "specific" antibody image, blood pool and conventional liver scans were also obtained. After computer-based subtraction discrete hepatic metastases could be demonstrated in both patients, while in the second patient, the primary colonic tumour was also visualised for the first time. The study demonstrates the specific localisation of primary and secondary carcinoma of the colon with a radiolabelled monoclonal anti-tumour antibody and offers an improved method of specifically detecting tumours in man.
将一种放射性标记的单克隆抗体静脉注射到两名患有播散性结肠癌的患者体内，然后在连续三天获取系列闪烁扫描图。除了“特异性”抗体图像外，还进行了血池和常规肝脏扫描。通过计算机辅助减法，两名患者均显示出离散的肝转移灶，而在第二名患者中，原发性结肠肿瘤也首次得以显影。该研究证明了放射性标记的单克隆抗肿瘤抗体可特异性定位结肠原发性和继发性癌，并提供了一种在人体中特异性检测肿瘤的改进方法。
