Flynn P J, Frank M, Hughes R
Br J Anaesth. 1984 Jun;56(6):599-605. doi: 10.1093/bja/56.6.599.
Following induction of anaesthesia with methohexitone, and tracheal intubation facilitated by suxamethonium, atracurium 0.3 mg kg-1 was administered to 53 patients undergoing Caesarean section. Surgical relaxation and cardiovascular stability were good. On completion of surgery, recovery from neuromuscular blockade occurred spontaneously in 45 patients and in the remaining eight patients, neostigmine and atropine produced rapid and effective antagonism. There was no evidence of recurarization in any patient. In the neonates there were no adverse effects on Apgar scores or on the time to sustained respiration attributable to the use of atracurium . The drug concentration in the umbilical vein measured in 15 patients indicated that atracurium did not cross the placenta in amounts likely to be of clinical significance.
在使用甲己炔巴比妥诱导麻醉并在琥珀胆碱辅助下进行气管插管后，对53例行剖宫产手术的患者给予阿曲库铵0.3毫克/千克。手术松弛效果和心血管稳定性良好。手术结束时，45例患者神经肌肉阻滞自发恢复，其余8例患者使用新斯的明和阿托品产生了快速有效的拮抗作用。所有患者均未出现再次箭毒化的迹象。在新生儿中，未发现使用阿曲库铵对阿氏评分或持续呼吸时间有不良影响。对15例患者脐静脉中药物浓度的检测表明，阿曲库铵穿过胎盘的量不太可能具有临床意义。
