尿液pH值对氟卡尼排泄及其血清药代动力学的影响。
The influence of urinary pH on flecainide excretion and its serum pharmacokinetics.
作者信息
Muhiddin K A, Johnston A, Turner P
出版信息
Br J Clin Pharmacol. 1984 Apr;17(4):447-51. doi: 10.1111/j.1365-2125.1984.tb02370.x.
Abstract
The effect of urinary pH on flecainide excretion has been evaluated in six healthy subjects after a single oral dose of 300 mg flecainide administered as the acetate salt. The cumulative urinary excretion of unchanged flecainide under acidic conditions (134.0 +/- 16.1 mg; mean +/- s.e. mean) was significantly higher than under alkaline conditions (22.3 +/- 7.6 mg; mean +/- s.e. mean) (P less than 0.01). Under alkaline conditions, tmax (time to reach peak concentration) was reduced (P less than 0.01), while elimination half-life, AUC(0-32) and AUC(0-infinity) were increased (P less than 0.01).
摘要
在六名健康受试者单次口服300毫克醋酸盐形式的氟卡尼后，评估了尿液pH值对氟卡尼排泄的影响。在酸性条件下，未改变的氟卡尼累积尿排泄量（134.0±16.1毫克；平均值±标准误）显著高于碱性条件下（22.3±7.6毫克；平均值±标准误）（P<0.01）。在碱性条件下，达峰时间（tmax）缩短（P<0.01），而消除半衰期、AUC(0 - 32)和AUC(0 - ∞)增加（P<0.01）。
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