Jarjis H A, Blackburn N A, Redfern J S, Read N W
Br J Nutr. 1984 May;51(3):371-8. doi: 10.1079/bjn19840043.
The effects of incorporating Fybogel (3.5 and 7 g doses), Metamucil (7 g) or guar gum (2.5 and 14.5 g doses) in a drink containing 50 g glucose on plasma glucose, plasma insulin and gastric emptying were studied in thirty-eight normal volunteers. In addition, the effects of Fybogel (7 g) on glucose tolerance, plasma insulin and gastric emptying were measured in fourteen non-insulin-dependent diabetics. Both doses of guar gum significantly lowered plasma glucose and plasma insulin responses to the oral glucose load in normal subjects, although 14.5 g guar gum did not delay the half-time for gastric emptying. Neither Fybogel nor Metamucil had significant effects on plasma glucose responses in normal subjects. In addition, Fybogel (at either dose) had no significant effects on plasma insulin levels, or on gastric emptying in normal subjects or on plasma glucose and insulin responses in diabetic patients. The viscosity of ispaghula solutions ( Fybogel ) was lower than that of guar gum solutions.
在38名正常志愿者中，研究了将Fybogel（3.5克和7克剂量）、美达施（7克）或瓜尔胶（2.5克和14.5克剂量）加入含有50克葡萄糖的饮料中对血糖、血浆胰岛素和胃排空的影响。此外，在14名非胰岛素依赖型糖尿病患者中测量了Fybogel（7克）对葡萄糖耐量、血浆胰岛素和胃排空的影响。两种剂量的瓜尔胶均显著降低了正常受试者口服葡萄糖负荷后的血糖和血浆胰岛素反应，尽管14.5克瓜尔胶并未延迟胃排空的半衰期。Fybogel和美达施对正常受试者的血糖反应均无显著影响。此外，Fybogel（任一剂量）对正常受试者的血浆胰岛素水平、胃排空或糖尿病患者的血糖和胰岛素反应均无显著影响。洋车前子溶液（Fybogel）的粘度低于瓜尔胶溶液。
