血清素受体与大鼠胶质瘤克隆中的膜电发生偶联。
Serotonin-receptor coupled with membrane electrogenesis in a rat glioma clone.
作者信息
Ogura A, Amano T
出版信息
Brain Res. 1984 Apr 16;297(2):387-91. doi: 10.1016/0006-8993(84)90581-x.
PMID:6326946
Abstract
The electrophysiological consequences of serotonin application to glial cells in culture are described. Membrane hyperpolarization due to K+ permeability-increment was induced by serotonin in rat clonal glioma (C6-BU-1) cells. Similar response was recognized in some of rat cerebral cortical glial cells. Pharmacological examinations in the C6-BU-1 glioma cells suggested a participation of serotonin-receptors sharing properties known in neuronal receptors.
摘要
本文描述了血清素作用于培养的神经胶质细胞后的电生理效应。血清素可诱导大鼠克隆性胶质瘤（C6-BU-1）细胞因钾离子通透性增加而出现膜超极化。在部分大鼠大脑皮质神经胶质细胞中也观察到类似反应。对C6-BU-1胶质瘤细胞的药理学检测表明，血清素受体参与其中，这些受体具有一些已知的神经元受体特性。
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