Rumi L, Colmerauer M E, Pasqualini C D
Arch Geschwulstforsch. 1976;46(6):457-60.
An in vivo model was used which permits the growth of AKR lymphoma allografts inoculated within a glass cylinder subcutaneously implanted in BALB mice. Pretreatment of the host with acellular tumor extracts or tumor cells enclosed within a diffusion chamber significantly increased tumor incidence. On the contrary, donor spleen extracts did not alter tumor incidence while viable spleen cells within a diffusion chamber even prevented tumor development. It can be concluded that in this model a condition of maximal tumor enhancement can be attained with soluble tumor antigen but not with normal spleen extracts.
使用了一种体内模型，该模型允许接种在皮下植入BALB小鼠的玻璃圆筒内的AKR淋巴瘤同种异体移植物生长。用无细胞肿瘤提取物或置于扩散室中的肿瘤细胞对宿主进行预处理可显著提高肿瘤发生率。相反，供体脾提取物不会改变肿瘤发生率，而置于扩散室中的活脾细胞甚至可阻止肿瘤发展。可以得出结论，在该模型中，可溶性肿瘤抗原可达到最大肿瘤增强状态，而正常脾提取物则不能。
