聚（ADP - 核糖）合成酶的DNA结合结构域对HeLa细胞裂解物中准确转录起始的影响。
Effect of the DNA-binding domain of poly(ADP-ribose)synthetase on accurate transcription initiation in a HeLa cell lysate.
作者信息
Ohtsuki M, Sekimizu K, Agemori M, Shizuta Y, Natori S
出版信息
FEBS Lett. 1984 Mar 26;168(2):275-7. doi: 10.1016/0014-5793(84)80261-6.
PMID:6327367
Abstract
The effect of papain-digested fragments of poly(ADP-ribose)synthetase on accurate transcription initiation by RNA polymerase II was studied using a HeLa cell lysate. It was found that the DNA-binding domain of the enzyme, like the intact enzyme, preferentially suppressed random transcription initiation, whereas the automodification domain had no effect on transcription.
摘要
使用HeLa细胞裂解物研究了聚（ADP-核糖）合成酶的木瓜蛋白酶消化片段对RNA聚合酶II精确转录起始的影响。发现该酶的DNA结合结构域与完整酶一样，优先抑制随机转录起始，而自身修饰结构域对转录没有影响。
Zotero 插件