Aleporou V, Maclean N
J Embryol Exp Morphol. 1978 Feb;43:221-31.
Serum from normal Xenopus, when injected into anaemic Xenopus, causes reduction in both DNA and protein synthesis in erythroid cells as indicated by in vitro culture of the blood cells. Experiments with erythrocyte-conditioned medium, reveal that this inhibitory substance can be recovered from mature erythrocytes. Sephadex G-25 fractionation of normal serum and haemolysate demonstrates that the inhibitory factor consists of molecules of low molecular weight, and experiments with with cells of Xenopus kidney reveal that the feedback inhibition may be tissue specific to erythroid cells.
将正常非洲爪蟾的血清注射到贫血的非洲爪蟾体内时，如血细胞体外培养所示，会导致红细胞系细胞中的DNA和蛋白质合成均减少。对红细胞条件培养基进行的实验表明，这种抑制物质可以从成熟红细胞中回收。对正常血清和溶血产物进行葡聚糖G - 25分级分离表明，抑制因子由低分子量分子组成，并且对非洲爪蟾肾细胞进行的实验表明，反馈抑制可能对红细胞系细胞具有组织特异性。
