Ciechanover A, Finley D, Varshavsky A
J Cell Biochem. 1984;24(1):27-53. doi: 10.1002/jcb.240240104.
In this review we briefly describe the lysosomal system, consider the evidence for multiplicity of protein degradation pathways in vivo, discuss in detail the ubiquitin-mediated pathway of intracellular ATP-dependent protein degradation, and also the possible significance of ubiquitin-histone conjugates in chromatin. For detailed discussions of the various characteristics and physiological roles of intracellular protein breakdown, the reader is referred to earlier reviews [1-7] and reports of recent symposia [8-10]. Information on the ubiquitin system prior to 1981 was described in an earlier review [11]. Hershko has briefly reviewed more recent information [12].
在本综述中，我们简要描述溶酶体系统，考量体内蛋白质降解途径多样性的证据，详细讨论泛素介导的细胞内ATP依赖性蛋白质降解途径，以及泛素-组蛋白共轭物在染色质中的可能意义。关于细胞内蛋白质分解的各种特征和生理作用的详细讨论，请读者参考早期的综述[1-7]以及近期研讨会的报告[8-10]。1981年之前关于泛素系统的信息在早期综述[11]中有描述。赫什科曾简要回顾了更新的信息[12]。
