Nakashima T, Kojiro M
Nihon Geka Gakkai Zasshi. 1983 Sep;84(9):939-42.
The discovery of alpha-fetoprotein and hepatitis B virus related antigens, and the development of diagnostic techniques in the past decade brought a new epoch in the study of hepatocellular carcinoma (HCC). Therefore, pathology of HCC should be re-investigated in accordance with the development of clinical aspects. In this paper, we have described the pathology of HCC based on both autopsy and surgical materials with special reference to angioarchitecture, unusual tumor growth, and histological growth pattern of HCC. Primary tumor, tumor thrombi in the portal vein and the hepatic vein, and intrahepatic metastasis receive arterial blood supply through arterial tumor vessels deriving from the hepatic artery. Unusual tumor growths, such as intrabile duct and intra-atrial tumor growths, have become relatively common, and tumor casts in the bile duct and the right atrium also receive arterial blood supply through arterial tumor vessels. histological growth pattern of HCC can be classified into three types; sinusoidal type, replacing type, and pseudoencapsulated type. The frequency of remote metastasis is different in each type.
甲胎蛋白和乙型肝炎病毒相关抗原的发现以及过去十年诊断技术的发展为肝细胞癌（HCC）的研究带来了新的时代。因此，应根据临床研究的进展对HCC的病理学进行重新研究。在本文中，我们基于尸检和手术材料描述了HCC的病理学，特别提及了血管结构、异常肿瘤生长以及HCC的组织学生长模式。原发性肿瘤、门静脉和肝静脉中的瘤栓以及肝内转移灶通过源自肝动脉的肿瘤血管获得动脉血供。异常肿瘤生长，如胆管内和心房内肿瘤生长，已变得相对常见，胆管和右心房内的肿瘤栓子也通过肿瘤血管获得动脉血供。HCC的组织学生长模式可分为三种类型：窦状型、替代型和假包膜型。每种类型远处转移的发生率各不相同。
