2-脱氧半乳糖对组成型合成半乳糖代谢酶的酿酒酵母细胞的毒性。
Toxicity of 2-deoxygalactose to Saccharomyces cerevisiae cells constitutively synthesizing galactose-metabolizing enzymes.
作者信息
Platt T
出版信息
Mol Cell Biol. 1984 May;4(5):994-6. doi: 10.1128/mcb.4.5.994-996.1984.
Abstract
Analysis of 400 independent spontaneous mutations conferring 2-deoxygalactose resistance upon cells constitutive for the galactose pathway suggests that toxicity is due to 2-deoxygalactose-1-phosphate. Selection for and against growth on galactose in the same strain is now possible; application to systems with transcriptional or translational gene fusions to galactokinase are discussed.
摘要
对400个独立自发突变进行分析，这些突变赋予半乳糖途径组成型细胞2-脱氧半乳糖抗性，结果表明毒性是由2-脱氧半乳糖-1-磷酸引起的。现在有可能在同一菌株中选择有利于和不利于在半乳糖上生长的情况；文中讨论了其在与半乳糖激酶进行转录或翻译基因融合的系统中的应用。
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