反向回旋酶——一种能将正向超螺旋引入DNA的拓扑异构酶。
Reverse gyrase--a topoisomerase which introduces positive superhelical turns into DNA.
作者信息
Kikuchi A, Asai K
出版信息
Nature. 1984;309(5970):677-81. doi: 10.1038/309677a0.
DOI:10.1038/309677a0
PMID:6328327
Abstract
An enzymatic activity which converts closed circular DNA into a positively supercoiled form is present in cellular extracts of Sulfolobus, an acidothermophilic archaebacterium. This novel enzyme is a type II DNA topoisomerase and is active only at temperatures greater than 55 degrees C, in the presence of ATP and Mg2+.
摘要
嗜酸嗜热古细菌硫磺叶菌的细胞提取物中存在一种能将闭环DNA转化为正超螺旋形式的酶活性。这种新型酶是一种II型DNA拓扑异构酶，仅在ATP和Mg2+存在的情况下，于温度高于55摄氏度时具有活性。
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