Gerdeaux M, Lemaire F, Matamis D, Lampron N, Teisseire B, Becker J, Harf A
Presse Med. 1984 May 19;13(21):1315-8.
Hypoxemia in the acute respiratory distress syndrome may be due to a variety of causes: trùe pulmonary shunt, decreased ventilation/perfusion ratios, impaired diffusion and/or fall of mixed venous oxygen. In order to sort out these different tension mechanisms, 18 patients with acute respiratory distress syndrome were explored by the inert gas method. In 6 of them hypoxemia was due to a true shunt (35 +/- 10%). The remaining 12 patients also had a true shunt (26.5 +/- 9.5%), but 4.5% of the cardiac output was distributed to areas with a ventilation/perfusion ratio between 0.1 and 0.005. Thus, in these 18 patients with acute respiratory distress, hypoxemia could be explained essentially by a true shunt.
真性肺分流、通气/灌注比降低、弥散受损和/或混合静脉血氧含量下降。为了区分这些不同的机制，采用惰性气体法对18例急性呼吸窘迫综合征患者进行了研究。其中6例患者的低氧血症是由真性分流所致（35±10%）。其余12例患者也存在真性分流（26.5±9.5%），但心输出量的4.5%分布于通气/灌注比在0.1至0.005之间的区域。因此，在这18例急性呼吸窘迫患者中，低氧血症基本上可由真性分流来解释。
