Hasler F
Schweiz Med Wochenschr. 1984 Apr 14;114(15):520-3.
Epstein-Barr virus (EBV) is regularly associated with Burkitt's lymphoma (nasopharyngeal carcinoma) and has been extensively documented as causal in infectious mononucleosis. Recently it has become evident that this virus is associated or handled differently in patients with a variety of immunological disorders. If the mechanisms that normally limit the effects of EBV infection are blunted, as in rheumatoid arthritis, antibody responses to EBV induced cellular antigens are significantly higher than in healthy individuals. In the host with more profound immunosuppression a polyclonal B cell lymphoproliferation takes place which may progress to the monoclonal proliferation of true lymphoma.
爱泼斯坦-巴尔病毒（EBV）通常与伯基特淋巴瘤（鼻咽癌）相关，并且在传染性单核细胞增多症中作为病因已被广泛记录。最近，很明显这种病毒在患有各种免疫紊乱的患者中存在不同的关联或表现。如果正常限制EBV感染影响的机制减弱，如在类风湿性关节炎中，对EBV诱导的细胞抗原的抗体反应明显高于健康个体。在免疫抑制更严重的宿主中，会发生多克隆B细胞增殖，这可能会发展为真正淋巴瘤的单克隆增殖。
