Kohri K, Kataoka K, Iguchi M, Yachiku S, Kurita T, Sonoda T
Urol Int. 1984;39(1):1-4. doi: 10.1159/000280932.
Parathyroid hormone is concerned with urolithiasis, and regulated by serum ionized calcium concentration. We thought that parathyroid hormone might also be regulated by a hormone. 1 mg of ACTH injection was given intramuscularly to 6 patients with primary hyperparathyroidism, 6 patients with urolithiasis, and 5 control subjects. Serum calcium significantly increased 2 h after ACTH injection in primary hyperparathyroidism. However in the other two groups, an increase of serum calcium was not observed. Parathyroid hormone increased after ACTH injection in most subjects of all three groups. Calcium concentration in a culture medium of parathyroidectomy increased in 4 cases, and the parathyroid hormone concentration in the culture medium increased in 3 cases after ACTH addition. From these data, we believe that ACTH directly influences the parathyroid glands, and that calcium is released from the parathyroid cells. Therefore, the decrease in calcium concentration in the parathyroid cells activates the excretion of parathyroid hormone. The fact that serum parathyroid hormone increases in most subjects in all groups supports our hypothesis, namely that ACTH acts directly on the parathyroid gland.
甲状旁腺激素与尿石症有关，并受血清离子钙浓度调节。我们认为甲状旁腺激素可能也受一种激素调节。对6例原发性甲状旁腺功能亢进患者、6例尿石症患者和5例对照受试者进行了1毫克促肾上腺皮质激素（ACTH）的肌肉注射。原发性甲状旁腺功能亢进患者在注射ACTH后2小时血清钙显著升高。然而，在其他两组中，未观察到血清钙升高。在所有三组的大多数受试者中，注射ACTH后甲状旁腺激素升高。在4例甲状旁腺切除术后的培养基中钙浓度升高，添加ACTH后3例培养基中的甲状旁腺激素浓度升高。从这些数据来看，我们认为ACTH直接影响甲状旁腺，并且钙从甲状旁腺细胞中释放出来。因此，甲状旁腺细胞中钙浓度的降低激活了甲状旁腺激素的分泌。所有组中大多数受试者血清甲状旁腺激素升高这一事实支持了我们的假设，即ACTH直接作用于甲状旁腺。
