Lindemalm C S, Björkholm M, Holm G, Johansson B, Mellstedt H
Acta Radiol Oncol. 1983;22(6):455-9. doi: 10.3109/02841868309135970.
Monocyte depleted blood lymphocytes were analyzed in 28 patients with non-Hodgkin's lymphoma in early unmaintained complete clinical remission, in 8 long-term complete remission patients, and in 31 age-matched healthy controls, by SRBC rosetting and DNA synthesis induced by concanavalin A, pokeweed mitogen and PPD antigen. The median observation time from testing was 22 months (range 10-49 months). Early complete remission patients with a normal mitogen induced lymphocyte stimulation remained free of relapses. In contrast, patients who relapsed during the observation period had lymphocytopenia (p less than 0.05), reduced lymphocyte responses to mitogen (p less than 0.001) and to PPD antigen (p less than 0.05) as compared with healthy controls. Long-term complete remission patients did not differ from healthy controls with respect to lymphocyte counts and response to mitogen stimulation.
通过SRBC玫瑰花结试验以及伴刀豆球蛋白A、商陆有丝分裂原和结核菌素纯蛋白衍生物抗原诱导的DNA合成，对28例处于未经维持治疗的早期完全临床缓解期的非霍奇金淋巴瘤患者、8例长期完全缓解患者以及31例年龄匹配的健康对照者的单核细胞耗竭血淋巴细胞进行了分析。自检测起的中位观察时间为22个月（范围10 - 49个月）。有丝分裂原诱导淋巴细胞刺激正常的早期完全缓解患者未出现复发。相比之下，与健康对照者相比，在观察期内复发的患者存在淋巴细胞减少（p < 0.05）、淋巴细胞对有丝分裂原的反应降低（p < 0.001）以及对结核菌素纯蛋白衍生物抗原的反应降低（p < 0.05）。长期完全缓解患者在淋巴细胞计数以及对有丝分裂原刺激的反应方面与健康对照者无差异。
