Rasmuson T, Björk G R, Damber L, Holm S E, Jacobsson L, Jeppsson A, Stigbrand T, Westman G
Acta Radiol Oncol. 1984;23(1):27-32. doi: 10.3109/02841868409135981.
The biologic markers carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA), placental alkaline phosphatase ( PLAP ) and pseudouridine were analysed in 37 patients with colorectal carcinoma. CEA, TPA and PLAP were derived from the serum and pseudouridine from the urine. The incidence of all four markers increased with advancing stages of the disease. Patients with distant metastases had elevated levels of CEA, TPA, PLAP and pseudouridine in 85, 27, 18 and 33 per cent of the total cases, respectively. When survival was compared, patients with 2 to 4 elevated markers had shorter survival than those with none or only one elevated marker.
对37例结直肠癌患者的生物标志物癌胚抗原（CEA）、组织多肽抗原（TPA）、胎盘碱性磷酸酶（PLAP）和假尿苷进行了分析。CEA、TPA和PLAP取自血清，假尿苷取自尿液。所有这四种标志物的发生率均随疾病分期的进展而增加。发生远处转移的患者中，CEA、TPA、PLAP和假尿苷水平升高的分别占总病例数的85%、27%、18%和33%。在比较生存率时，有2至4种标志物升高的患者比没有或只有一种标志物升高的患者生存期更短。
