Rasmuson T, Björk G R, Damber L, Jacobsson L, Jeppsson A, Stigbrand T, Westman G
Department of Oncology, University of Umeå, Sweden.
Acta Oncol. 1987;26(4):261-7. doi: 10.3109/02841868709089972.
In 104 patients with breast cancer, carcinoembryonic antigen (CEA), placental alkaline phosphatase (PLAP) and the carbohydrate antigen CA-50 were analysed in serum. Excretion of the modified nucleoside, pseudouridine, was analysed in urine. The patients were subdivided in three different clinical stages according to disease manifestations. Levels of CEA and pseudouridine correlated to clinical stage and 58 per cent of the patients with distant metastases had elevated levels of CEA, compared with 36 per cent for pseudouridine. For PLAP and CA-50, the levels did not show any clear correlation to clinical stage. Increased activity of PLAP correlated strongly to tobacco smoking. A decrease in the level of CEA was observed following radical mastectomy. Increase in CEA levels predicted relapse in 5 out of 14 patients within about 3 to 6 months. In patients with tumor manifestations, elevated CEA levels predicted an inferior prognosis compared to those with ordinary levels.
对104例乳腺癌患者的血清癌胚抗原（CEA）、胎盘碱性磷酸酶（PLAP）和糖类抗原CA - 50进行了分析。对尿液中修饰核苷假尿苷的排泄情况进行了分析。根据疾病表现将患者分为三个不同的临床阶段。CEA和假尿苷水平与临床阶段相关，58%发生远处转移的患者CEA水平升高，而假尿苷水平升高的患者为36%。对于PLAP和CA - 50，其水平与临床阶段未显示出明显相关性。PLAP活性增加与吸烟密切相关。根治性乳房切除术后观察到CEA水平下降。14例患者中有5例在约3至6个月内CEA水平升高预示复发。在有肿瘤表现的患者中，与CEA水平正常的患者相比，CEA水平升高预示预后较差。
