Fisher B, Cheung A Y
Acta Radiol Oncol. 1984;23(1):43-8. doi: 10.3109/02841868409135984.
In this retrospective investigation of 51 female patients with Hodgkin's disease, the age of the patient at the time of primary treatment and the extent of radiation therapy were the two most important factors determining post-therapy ovarian function. Favourable indicators of ovarian preservation included young age, especially premenarchal , at the time of primary therapy, and irradiation confined to above the pelvic brim, whereas, age over 40 and irradiation below the pelvic brim predicted high probability of ovarian failure. Overall, 55 per cent of female patients under the age of 50 treated with chemotherapy alone or with radiation therapy above the pelvic brim retained normal ovarian function. The stage of disease at presentation and the post-therapy status of disease had no apparent effect on subsequent menstrual function.
在这项对51例霍奇金病女性患者的回顾性研究中，初次治疗时患者的年龄以及放射治疗范围是决定治疗后卵巢功能的两个最重要因素。卵巢保留的有利指标包括初次治疗时年龄较轻，尤其是青春期前，以及照射范围局限于骨盆边缘以上，而40岁以上且照射范围在骨盆边缘以下则预示卵巢功能衰竭的可能性很高。总体而言，仅接受化疗或接受骨盆边缘以上放射治疗的50岁以下女性患者中，55%保留了正常卵巢功能。疾病初发时的分期以及治疗后疾病状态对后续月经功能无明显影响。
