Chu A M, Cope O, Russo R, Lew R
Am J Clin Oncol. 1984 Jun;7(3):221-9. doi: 10.1097/00000421-198406000-00006.
One hundred forty-six women with Stage I and Stage II breast cancer received radical radiotherapy after having excisional biopsy ( lumpectomy ) at Massachusetts General Hospital between 1956-1978. They were grouped according to age: those younger than 49 years and those older than 50 years. The 5-year survival rates were 93 and 73% for patients with Stage I and Stage II cancer, respectively; the corresponding 5-year relapse survival rates were 75 and 56%. The local recurrence rate was 8% in patients with Stage I disease and 17% in those with Stage II disease. Survival was not significantly affected by patients' age, by the presence or absence of blood vessel or lymphatic involvement, or by the addition of adjuvant chemotherapy. No major complications occurred. Modification in radiation dose and technique resulted in improved overall survival and local control. Limited surgery followed by radical radiation therapy offers a therapeutically effective, cosmetically acceptable alternative to radical surgery for early stage breast cancer.
1956年至1978年间，146例I期和II期乳腺癌女性患者在马萨诸塞州总医院接受切除活检（肿块切除术）后接受了根治性放疗。她们按年龄分组：年龄小于49岁和年龄大于50岁。I期和II期癌症患者的5年生存率分别为93%和73%；相应的5年复发生存率分别为75%和56%。I期疾病患者的局部复发率为8%，II期疾病患者为17%。患者年龄、有无血管或淋巴管受累以及是否加用辅助化疗对生存率均无显著影响。未发生重大并发症。放疗剂量和技术的改进提高了总生存率和局部控制率。对于早期乳腺癌，有限手术加根治性放疗为根治性手术提供了一种治疗有效且美容效果可接受的替代方案。
