Ann Surg. 1986 Aug;204(2):136-47.
Between 1977 and 1983, 150 women with primary breast cancer, ranging in age from 26 to 84, were treated with a breast-sparing procedure involving lumpectomy, axillary node dissection, external beam radiotherapy, and 192-iridium implant. Median follow-up to date is 46+ months, with a range of 14 to 96+ months. All surviving patients have been followed for a minimum of 24+ months. Actuarial disease-free survival projected to 8 years is 79% for the entire group, 100% for the five noninfiltrating intraductal cancer patients, 97% for the 71 Stage I patients, and 68% for the 74 Stage II patients. Eighteen of the 150 patients (12%) have developed local recurrences thus far. Five (3%) have developed second, nonbreast, primary tumors. This community-based study, examined together with other published reports of similar procedures and compared to published results following mastectomy, helps confirm lumpectomy-radiotherapy as a legitimate approach to the management of primary breast cancer.
1977年至1983年间，150名年龄在26岁至84岁之间的原发性乳腺癌女性接受了保乳手术，包括肿块切除术、腋窝淋巴结清扫术、外照射放疗和铱-192植入。目前的中位随访时间为46 +个月，范围为14至96 +个月。所有存活患者的随访时间至少为24 +个月。整个组预计8年的无病生存率为79%，5名非浸润性导管内癌患者为100%，71名I期患者为97%，74名II期患者为68%。到目前为止，150名患者中有18名（12%）出现了局部复发。5名（3%）发生了第二种非乳腺原发性肿瘤。这项基于社区的研究，与其他关于类似手术的已发表报告一起进行检查，并与乳房切除术后的已发表结果进行比较，有助于证实肿块切除-放疗是原发性乳腺癌治疗的一种合理方法。
