Berczi I, Nagy E, Asa S L, Kovacs K
Arthritis Rheum. 1984 Jun;27(6):682-8. doi: 10.1002/art.1780270612.
Adjuvant arthritis was induced in female Fisher rats by injecting their right hind paw with 0.1 ml Freund's complete adjuvant. The development of adjuvant arthritis was inhibited by hypophysectomy and by daily treatment of intact animals with the dopaminergic agent bromocriptine. Adjuvant arthritis developed normally if hypophysectomized or bromocriptine-suppressed animals were treated with either prolactin or growth hormone. Additional treatment with adrenocorticotropic hormone inhibited this restoration. Treatment of hypophysectomized rats with follicle-stimulating hormone, luteinizing hormone, and thyroid-stimulating hormone had no effect. These results indicate that prolactin and/or growth hormone are necessary for the development of adjuvant arthritis, whereas adrenocorticotropic hormone has an inhibitory effect.
通过给雌性费希尔大鼠的右后爪注射0.1毫升弗氏完全佐剂诱导佐剂性关节炎。垂体切除术以及用多巴胺能药物溴隐亭对完整动物进行每日治疗可抑制佐剂性关节炎的发展。如果对垂体切除或溴隐亭抑制的动物用催乳素或生长激素进行治疗，佐剂性关节炎会正常发展。额外使用促肾上腺皮质激素治疗可抑制这种恢复。用促卵泡激素、促黄体生成素和促甲状腺激素治疗垂体切除的大鼠没有效果。这些结果表明，催乳素和/或生长激素是佐剂性关节炎发展所必需的，而促肾上腺皮质激素具有抑制作用。
