用I-131标记的抗肿瘤抗体对原发性肾细胞癌进行放射性核素显像。
Radionuclide imaging of primary renal-cell carcinoma by I-131-labeled antitumor antibody.
作者信息
Belitsky P, Ghose T, Aquino J, Norvell S T, Blair A H
出版信息
J Nucl Med. 1978 Apr;19(4):427-30.
PMID:632934
Abstract
A goat antibody against human renal-cell carcinoma reacted on immunofluorescence with renal-cell carcinomas from 20 patients, but not with normal adult human tissues, including kidney. After i.v. administration the I-131-linked antibody showed preferential tumor localization in six of seven patients with primary renal carcinoma. Labeled antitumor antibodies may have the specificity for tumor imaging that current radiopharmaceuticals lack.
摘要
一种抗人肾细胞癌的山羊抗体在免疫荧光检测中与20例患者的肾细胞癌发生反应，但不与包括肾脏在内的正常成人组织发生反应。静脉注射后，与碘-131连接的抗体在7例原发性肾癌患者中的6例中显示出肿瘤的优先定位。标记的抗肿瘤抗体可能具有目前放射性药物所缺乏的肿瘤成像特异性。
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