双硫仑多发性神经病
Disulfiram polyneuropathy.
作者信息
van Rossum J, Roos R A, Bots G T
出版信息
Clin Neurol Neurosurg. 1984;86(2):81-7. doi: 10.1016/0303-8467(84)90070-2.
PMID:6329580
Abstract
Disulfiram in generally accepted maintenance doses in alcoholism may produce a rather severe polyneuropathy. In addition to the 39 literature cases, 5 personal patients were examined. Detailed clinical findings are given and the frequent permanent sequelae are emphasized. In 2 patients sural nerve biopsies were studied (including electromicroscopical examination) revealing a primary axonal lesion. In the treatment of alcohol addiction one should be aware of this complication.
摘要
在酒精中毒治疗中，常用维持剂量的双硫仑可能会引发相当严重的多发性神经病。除了文献报道的39例病例外，还对5例个人患者进行了检查。给出了详细的临床发现，并强调了常见的永久性后遗症。对2例患者进行了腓肠神经活检（包括电镜检查），发现原发性轴索病变。在治疗酒精成瘾时应注意这种并发症。
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