Cowie V J, Pointon R C
Clin Radiol. 1984 Jul;35(4):331-3. doi: 10.1016/s0009-9260(84)80116-6.
Eighty-two patients with adenoid cystic carcinoma treated by a radical course of radiotherapy are reviewed. In 44 cases the tumour arose in the major salivary glands and, of these, 77% had an incomplete surgical excision and 23% had only a tumour biopsy before radiotherapy. Thirty-eight tumours arose in the minor salivary glands and, of these, 18% had an incomplete surgical excision and 82% a biopsy only before treatment. Primary tumour control was achieved in 67% of patients at 5 years. The local control was significantly better in patients who had an incomplete surgical excision: 86% compared with 37% at 5 years. The local control of tumours arising in the major salivary glands is significantly better than that of tumours arising in the minor glands, but this difference is explained by more patients with major gland tumours having had incomplete surgery. For patients treated after only a biopsy, local tumour control was achieved in 37%, demonstrating the radioresponsiveness of this type of carcinoma. No difference in survival was demonstrated in patients with major or minor gland tumours. Despite local tumour control, 43% of patients with major gland tumours died from metastatic disease. The commonest cause of death of patients with minor gland tumours was local failure.
对82例接受根治性放疗的腺样囊性癌患者进行了回顾性研究。44例肿瘤发生于大唾液腺，其中77%患者手术切除不彻底，23%患者放疗前仅行肿瘤活检。38例肿瘤发生于小唾液腺，其中18%患者手术切除不彻底，82%患者治疗前仅行活检。5年时67%的患者实现了原发肿瘤控制。手术切除不彻底的患者局部控制明显更好：5年时为86%，而手术切除彻底的患者为37%。大唾液腺肿瘤的局部控制明显优于小唾液腺肿瘤，但这种差异是因为更多大唾液腺肿瘤患者手术不彻底。仅接受活检后治疗的患者中，37%实现了局部肿瘤控制，表明这类癌对放疗有反应。大唾液腺或小唾液腺肿瘤患者的生存率无差异。尽管实现了局部肿瘤控制，但43%的大唾液腺肿瘤患者死于转移性疾病。小唾液腺肿瘤患者最常见的死亡原因是局部复发。
