ElSohly M A, Harland E C, Benigni D A, Waller C W
Curr Eye Res. 1984 Jun;3(6):841-50. doi: 10.3109/02713688409000797.
Thirty-two different cannabinoids were tested for their ability to reduce intraocular pressure (IOP) in the rabbit. These included many of delta 9- and delta 8-THC derivatives and metabolites along with other natural and synthetic cannabinoids. In addition, some non-cannabinoid constituents of Cannabis were screened using the same model. All compounds were administered intravenously, while only a few were tested topically in mineral oil. Water soluble derivatives of delta 9- and delta 8-THC were prepared and tested topically in aqueous solution. The data revealed that certain derivatives of delta 9-and delta 8-THC were more active in lowering IOP than the parent cannabinoids. In addition, compounds other than delta 9- and delta 8-THC and their derivatives were shown to have activity.
对32种不同的大麻素进行了测试，以考察它们降低兔眼内压（IOP）的能力。这些大麻素包括许多δ9-和δ8-四氢大麻酚（THC）衍生物及代谢物，以及其他天然和合成大麻素。此外，还使用相同模型对大麻的一些非大麻素成分进行了筛选。所有化合物均通过静脉给药，只有少数在矿物油中进行了局部测试。制备了δ9-和δ8-THC的水溶性衍生物，并在水溶液中进行了局部测试。数据显示，δ9-和δ8-THC的某些衍生物在降低眼内压方面比母体大麻素更具活性。此外，除δ9-和δ8-THC及其衍生物外的其他化合物也显示具有活性。
