Colasanti B K
Department of Ophthalmology, West Virginia University Health Sciences Center North, Morgantown.
J Ocul Pharmacol. 1990 Winter;6(4):259-69. doi: 10.1089/jop.1990.6.259.
Both delta 9-tetrahydrocannabinol (delta 9-THC) and cannabigerol, two naturally occurring marihuana cannabinoids, produced only a modest fall in intraocular pressure after acute topical application to the eyes of cats. After chronic administration unilaterally to the cornea via Alzet osmotic minipumps and connecting extraocular cannulas, however, a considerable fall in ocular tension amounting to 4 to 7 mm Hg occurred. After systemic administration of delta 9-THC to rats, polyspike discharges appeared in the cortical electroencephalogram initially during wakefulness and behavioral depression. These polyspikes subsequently became evident within rapid eye movement sleep episodes. Cannabigerol was devoid of this effect. After removal of either sympathetic or parasympathetic input to the eyes of cats, the intraocular pressure lowering effect of delta 9-THC was not changed. Neither delta 9-THC nor cannabigerol altered the rate of formation of aqueous humor. On the other hand, both cannabinoids produced a two-to three-fold increase in aqueous outflow facility. These results suggest that cannabigerol and related cannabinoids may have therapeutic potential for the treatment of glaucoma.
Δ⁹-四氢大麻酚（Δ⁹-THC）和大麻二酚这两种天然存在的大麻素，在急性局部应用于猫的眼睛后，仅使眼压有适度下降。然而，通过Alzet渗透微型泵和连接眼外插管单侧慢性给药至角膜后，眼压显著下降达4至7毫米汞柱。给大鼠全身注射Δ⁹-THC后，最初在清醒和行为抑制期间，皮层脑电图中出现多棘波放电。这些多棘波随后在快速眼动睡眠期间变得明显。大麻二酚没有这种作用。去除猫眼睛的交感或副交感神经输入后，Δ⁹-THC的降眼压作用没有改变。Δ⁹-THC和大麻二酚都没有改变房水生成速率。另一方面，两种大麻素均使房水流出易度增加两到三倍。这些结果表明，大麻二酚及相关大麻素可能具有治疗青光眼的潜力。
