Hanson J W, Streissguth A P, Smith D W
J Pediatr. 1978 Mar;92(3):457-60. doi: 10.1016/s0022-3476(78)80449-1.
Information on fetal hazards arising from moderate or low levels of maternal alcohol consumption is unavailable in man. In order to study this question an unselected group of pregnant women was interviewed during pregnancy regarding their alcohol intake. At the time of delivery pairs of high-risk and control infants were examined without knowledge of maternal drinking history. Of 163 infants examined, 11 were judged clinically to show signs compatible with a prenatal effect of alcohol on growth and morphogenesis. Nine of these 11 came from the high-risk drinking group. Only two of these infants were classified as having the fetal alcohol syndrome, and each of the mothers was a very heavy drinker. The other seven infants, who showed lesser alterations of growth and morphogenesis suggestive of fetal alcohol syndrome, were born to women who reported drinking an average of one ounce or more of absolute alcohol per day in the month prior to recognition of pregnancy. These results indicate that both moderate and high levels of alcohol intake during early pregnancy may result in alterations of growth and morphogenesis in the fetus.
目前尚无关于孕妇中度或低度饮酒对胎儿危害的相关信息。为了研究这个问题，在孕期对一组未经挑选的孕妇进行了访谈，询问她们的酒精摄入量。在分娩时，对高危婴儿和对照婴儿进行检查，且检查人员并不知晓产妇的饮酒史。在接受检查的163名婴儿中，有11名在临床上被判定表现出与酒精对生长和形态发生的产前影响相符的体征。这11名婴儿中有9名来自高危饮酒组。其中只有2名婴儿被归类为患有胎儿酒精综合征，且每位母亲都是酗酒者。另外7名婴儿表现出较轻的生长和形态改变，提示胎儿酒精综合征，他们的母亲在怀孕前一个月报告平均每天饮用一盎司或更多纯酒精。这些结果表明，怀孕早期中度和高度饮酒都可能导致胎儿生长和形态发生改变。
