视黄酸对产生病毒和不产生病毒细胞系中爱泼斯坦-巴尔病毒诱导的不同抑制作用。
Differential inhibitory effects of retinoic acid on Epstein-Barr virus induction in producer and nonproducer cell lines.
作者信息
Morigaki T, Sugawara K, Ito Y
出版信息
Intervirology. 1984;22(1):56-60. doi: 10.1159/000149534.
PMID:6329997
Abstract
The effects of retinoic acid on Epstein-Barr virus (EBV) antigen induction by 12-O-tetradecanoyl-phorbol-13-acetate, 5-iodo-2'-deoxyuridine, and n-butyrate and by combinations of them were examined in two virus-producer and two nonproducer cell lines. Irrespective of the inducers used, the induction was markedly inhibited in the nonproducer lines and only weakly inhibited in the producer lines. The possible sites of action of retinoic acid are discussed.
摘要
在两种病毒产生细胞系和两种非产生细胞系中，研究了视黄酸对12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯、5 - 碘 - 2'- 脱氧尿苷、丁酸盐及其组合诱导爱泼斯坦 - 巴尔病毒（EBV）抗原的影响。无论使用何种诱导剂，在非产生细胞系中诱导作用均受到显著抑制，而在产生细胞系中仅受到微弱抑制。文中讨论了视黄酸可能的作用位点。
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