Kalager T, Digranes A, Bergan T, Solberg C O
J Antimicrob Chemother. 1984 May;13(5):479-85. doi: 10.1093/jac/13.5.479.
Following 4 g of ceftriaxone, given intravenously, to eight volunteers, the antibiotic concentration in serum, suction skin blister fluid and fluid from subcutaneously implanted threads was followed for 28 h. High and sustained levels were found in both serum and extravascular fluids; the mean maximum serum concentration was 448 mg/l, and the mean peak concentrations in blister and thread fluid were 94 mg/l and 63 mg/l, respectively. The terminal, half-lives were: serum 7.2 h, blister fluid 10.3 h and thread fluid 11.3 h. The total area under the concentration versus time curves for serum was 1636 mg X h/l. For blister and thread fluid the areas were 1573 mg X h/l and 808 mg X h/l. The results suggest a twice daily dosage regimen.
给8名志愿者静脉注射4克头孢曲松后，对血清、吸引的皮肤水疱液和皮下植入丝线中的液体中的抗生素浓度进行了28小时的跟踪监测。血清和血管外液体中均发现高且持续的浓度；平均最大血清浓度为448毫克/升，水疱液和丝线液中的平均峰值浓度分别为94毫克/升和63毫克/升。终末半衰期分别为：血清7.2小时、水疱液10.3小时和丝线液11.3小时。血清浓度-时间曲线下的总面积为1636毫克·小时/升。水疱液和丝线液的面积分别为1573毫克·小时/升和808毫克·小时/升。结果提示每日给药两次的方案。
